摘要
我们用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法,造成兔动脉粥样硬化(AS),观察到实验6周时,高血脂加免疫性动脉内皮损伤组(L+Ser组)兔血清透明质酸(HA)水平(513.4±78.8μg/ml)已明显升高,显著高于对照组(C组)(322.4±78.8μg/ml)和单纯食饵性高血脂组(L组)(349.2±72.8μg/ml)(P<0.01).实验16周时,L组(499.3±102.8μg/ml)和L+Ser组(572.4±74.8μg/ml)血清HA水平均明显升高,并以L+Ser组更明显,与C组(305.7±112.0μg/ml)比较,有显著(P<0.05)及非常显著(P<0.01)差异.L+Ser组主动脉AS病变程度(65.8±23.4%)也显著重于L组(37.1±16.1%)(P<0.05).血清HA测定可能有助于AS和缺血性心血管疾病的诊断和治疗观察.
We established the experimental atherosclerosis in rabbits by means of lipidemia administered andcombing lipidemia administered and serum of other origin IV repeatedly to make the immunopathologic endothelial injures. Considerably higher plasma level of hyaluronic acid (HA) (513.4±78.8pg/ml) was observed in thegroup combinging lipidemia administered and serum of other origin IV repeatedly (L+Ser group), comparedwith those in the control group (322.4±78. 8ug/ml) and the group with only lipidemis administered (L group)(349.2±72.8ug/ml) at six weeks after the experiment. Obviously higher plasma levels of HA were observed inboth L group (499.3±102.8μg/ml) and L+Ser group (572.4±74. 8μg/ml), compared with that (305.7 ±112.Oμg/ml) in the control group at sixteen weeks after the experiment. The atherosclerotic lesions (65.8±23.4%) of the aortas in L+Ser group were significantly more serious than those (37.1±16.1%) in L goup.Determination of the plasma level of HA may beatherosclersis and with ischemic heart disease.
