甘丙素在急性心肌梗塞发病中的临床意义

Clinical Significance of Galanin in the Pathogenesis of Acute Myocardial Infarction

本文测定31例急性心肌梗塞(AMI)患者血浆甘丙素(GAL)的放免活性.结果示AMI.患者急性期各次血浆GAL水平明显高于对照组,伴高血压、糖尿病和心功能不全者升高更显著,GAL和内皮素(ET)、血糖水平均呈正相关.实验性心肌梗塞大鼠血浆GAL、血清肌酸激酶(CK)、CK同功酶(CK-MB)、丙二醛(MDA)含量亦明显高于对照大鼠,用GAL抗血清治疗心梗大鼠,减少坏死面积45.4%和缩小了梗塞范围47.1%,亦明显降低了血浆GAL水平,抑制血清CK、CK-MB、MDA活性,提示早期阻断GAL的生物学效应,对防治AMI有重要意义.实验还发现牛磺酸对GAL亦有拮抗效用,显示牛磺酸有保护心肌细胞作用.

The level of plasma galanin (GAL) was studied in 31 cases with acute my-ocardial infarction (AMI). GAL level in the AMI group was significantly higher than that in the control group (P<0. 01~0. 001). In the group of AMI with hypertension,diabetes and heart failure,the plasma GAL level increased more obviously.It was discovered that the plas-ma GAL level was positively correlated with the plasma endothelin(ET) level,and also with the content of blood sugar. The effect of GAL-antiserum on myocardial infarction (MI) was investigated on infarct model produced by ligature of left anterior decending coronary arteries in rats. The results showed that the plasma level of GAL. CK,CK-MB and MDA elevated significantly in rats with MI,and GAL-antiserum administration reduced macrosis size (45. 4%) and infarct range (47. 1%) decreased the plasma activity of CK,CK-MB and MDA. It is suggested that GAL is an important factor which contributes to the pathogenesis of MI. Tau-rine was also found out to antagonize markedly the effects of GAL which suggests that tau-rine may exert myocardial cell protective action.