摘要
通过角叉菜胶诱发大鼠足水肿这一经典炎症模型,观察了基因工程重组人铜锌超氧化物歧化酶(Recombined Human Superoxide Dismutase;rh SOD)对非感染性炎症的抗炎作用,证实了静脉注射 rh SOD(7000 U/kg～10 000 U/kg)对大鼠足肿胀有明显抑制作用,实验组与对照组间有显著性差异(P<0.001),增加剂量和给药次数可提高抗炎效果.该结果为进一步探讨rh SOD抗放射线损伤的机制奠定了基础.
The anti-inflammatory activity of recombinent human superoxide dismutase (rh SOD)had been observed by using the carrageenan-induced foot-edema rat model. The results showed that rh SOD (i. v. 7 000 U^10 000U/kg) inhibited the rat foot-edema significantly. (F<0.001 between testgroup and control group). The anti-inflammatory activity can be raised by the increase of the dosage andthe time of administation of rh SOD.
关键词
基因工程
肿胀率
肿胀抑制率
超氧化物歧化酶
<Keyword>recombinent human superoxide dismutase
carrageenan-induced foot-edema
rate of sweeling
inhibitent rate of sweeling
