摘要
应用放射免疫分析(RIA)法检测64例肝炎后肝硬变患者血浆精氨酸加压素(AVP)含量.结果显示:肝硬变腹水组AVP水平明显高于肝硬变无腹水组及正常对照组(P<O.01和 P<0.001).肝硬变腹水组内生肌酐清除率(Ccr),24h尿钠排出量显著低于无腹水组(P<0.01和 P<O.001).Child肝功能分级,肝功能越差,血浆AVP含量越高.伴有腹水肝硬变患者血浆AVP水平与白蛋白及24 h尿钠水平呈显著性负相关,而与血清总胆红素、凝血酶原时间、肌酐及血清谷雨转氨酶(ALT)水平呈显著正相关.肝硬变水钠潴留与AVP分泌代谢紊乱有关.
<Abstract >The plasma levels of arginine vasopressin (AVP) were determined by radioimmunoassayin normal subjects and 64 patients with liver cirrhosis. The results revealed: mean AVP plasma level wassignify-cantly higher in 20 cirrhotic patients than that in normal subjects (35.9±11.74 pg/ml versus11.2±3.9 pg/ml,P<0.01). Plasma AVP was 70.3±5.84 pg/ml in 44 cirrhotic patients with ascites compared with 35.9±1.74 pg/ml in patients without ascites(P<0. 01). Urinary sodium concentrations and clearance rates of creatinine were significantly lower in cirrhotic patietnts with ascites thanthose in patients without ascites. The results suggested that elevation of circulating AVP might be oneof the important factors of sodium and water retention in liver cirrhosis.
关键词
肝硬变
精氨酸加压素
尿钠
腹水
<Keyword>liver cirrhosis
Arginine Vasopressin
Urinary sodium
Clearance retes of creatinine
