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奥美拉唑的药理及临床应用 被引量:1

THE EFFECT OF 25 CASES WITH PEPTIC ULCER TREATED WITH OMEPRAZOLE
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摘要 25 cases with peptic ulcer as a treating group were treated with omeprazole (OME) produced by Sanye pharmaceutical factory in Haikou, China and 6 cases with the same disease as a control group were treated with Losec produced by Astra pharmaceutical corporation in Sweden.All the patients were diagnosed by endoscope. In the treating group there were 6 cases with gastric ulcer(Gu)17 ones with duodenal ulcer (Du)and to ones with compound ulcer (Gu+Du) In the control group there was one case with Gu and 5 ones with Du,All the ulcers were in their active stage.The method of therapy was 20mg (1 capsul) orally per day in both groups.the course was 2 weeks (3 cases in treating group and two cases in control group)or 4 weeks (22 cases in freting group and 4cases in euntrol group),The result showed that the healing rate of the ulcers was 100% in both groups, the relieving time of the symptoms was almost the same in both groups and no obvious side effects were found in both groups too.we consider that the price of OME produced in china is rather cheaper than that of Losec so tliat the national OME may be hued as a substitution for Losec. 25 cases with peptic ulcer as a treating group were treated with omeprazole (OME) produced by Sanye pharmaceutical factory in Haikou, China and 6 cases with the same disease as a control group were treated with Losec produced by Astra pharmaceutical corporation in Sweden.All the patients were diagnosed by endoscope. In the treating group there were 6 cases with gastric ulcer(Gu)17 ones with duodenal ulcer (Du)and to ones with compound ulcer (Gu+Du) In the control group there was one case with Gu and 5 ones with Du,All the ulcers were in their active stage.The method of therapy was 20mg (1 capsul) orally per day in both groups.the course was 2 weeks (3 cases in treating group and two cases in control group)or 4 weeks (22 cases in freting group and 4cases in euntrol group),The result showed that the healing rate of the ulcers was 100% in both groups, the relieving time of the symptoms was almost the same in both groups and no obvious side effects were found in both groups too.we consider that the price of OME produced in china is rather cheaper than that of Losec so tliat the national OME may be hued as a substitution for Losec.
作者 郑健超
机构地区 海南省人民医院
出处 《海南医学》 CAS 1994年第3期175-178,共4页 Hainan Medical Journal
关键词 奥美拉唑 药理 临床应用 Omeprazole Losec peptic ulcer
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  • 1张尤历 刘厚珏 周康.幽门螺杆菌VacA基因型、cagA基因及其表达产物与不同类型胃十二指肠疾病的关系[J].中华消化杂志,1993,15(5):280-280.
  • 2Nastede R, Nastener M, Becker H,et al. 4th UEGW(M)[J]. Berlin,1995,1421(1226):2364.
  • 3卫生部药典委员会.中国药典 二部[M].北京:化学工业出版社,1995.附录177.
  • 4P Ling d berg.Stereosetective metabolism of omeprazole by human cytochrome P450 enzymes[J].J Mel Chem,1986,29(8):1327.

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