年龄、限食和噪声对大鼠肿瘤发生的影响

Effects of age, hyponutrition and noise on tumor incidence in rats

老年人各种死亡原因中,恶性肿瘤居前列,因此老化与肿瘤的关系一直被人们关注。人类大多数恶性肿瘤的发生率均随增龄而上升。但除年龄因素外,生活环境、饮食营养等都有不同程度的差异。为了探讨老化与肿瘤的关系,我们观察了在相同环境条件下生长的老、中和青年大鼠的肿瘤发生情况,以及长期限食和噪声对肿瘤发生的影响。材料和方法一、实验动物和分组 Wistar大鼠雌、雄各60只,由北京医科大学动物部提供。鼠龄12周,体重120 g左右。随机将雌、雄大鼠各分为非限食组、非限食噪声组。

Effects of hyponutrition and noise on tumorigenecity in rats at different age were studied. Cancer incidence was much higher in the aged group of rats than in the middle and young groups; significantly higher in the group with normal diet than in the group with hyponutrition and greatly higher in the group of hyponutrition with noise than in the group of hyponutrition without noise. No remarkable difference, however, was noticed between the groups of normal diet with noise and without noise. Breasts, lungs and alimentary tracts were the most common sites for various kinds of tumors to develop in rats. The machenism of hyponutrition and noise which promotes development of tumor in rats of different age-groups was discussed.