刺五加复方对低氧条件下鼠水电解质代谢的影响

Effects of Raeix Acanthopanacis Senticosi Compounds on Water-Electrolyte Metabolism and Related Hormones in Rats During Exposure to Hypoxia

为探讨用中药防治急救性高山病的效果，在模拟６０００ｍ高原低氧条件下，观察了刺五加复方对大鼠水电解质和相关激素的影响。结果表明，刺五加复方组醛固酮（ＡＬＤＯ）和心钠素（ＡＮＰ）的含量低于和明显低于缺氧对照组和葛方党参组（Ｐ＜０．０５）。缺氧对照组和复方党参组的脑肺水含量增加和明显增加（Ｐ＜０．０５），刺五加复方组的相应值改变不明显和略有减少（Ｐ＜０．０５）。缺氧对照组和复方党参组的脑肺Ｎａ＋含量增加和明显增加（Ｐ＜０．０５），刺五加复方组的相应值改变不明显。在４３９０ｍ高原低氧条件下，观察了刺五加复方对人尿量和尿蛋白含量的影响，结果显示，刺五加复方组的尿量多于对照组，尿蛋白的阳性发生率，明显低于缺氧对照组。以上结果提示，刺五加复方能明显改善低氧条件下的水电解质代谢。

Effects of radix acanthopanacis senticosi compounds(RASC)on water-lectrolyte metabolism and related hormones in rats were observed by exposure to a simu-lated altitude of 6000m. The results showed that increases of plasma aldosterone content and plasma atrial natriuretic peptide content were lower in the RASC group than that in hypoxia-control group and compounds dangshen group( P<0.05).Water contents in brain and lung significantly increased in the hypoxia control group and compounds dang- shen group ,while values of these targets did not alter or significantly decreased in the RASC group. Na+levels in brain and lung increased and significantly increased in the hypoxia control group and compounds dangshen group , but values of these targets did not change in the RASC group.Urine output was more and occurrence rate of urine protein was much lower(P<0.001 ) in the RASC group as compared with these in control group during exposure to altitude of 4390m in man.These results indicated that the RASC might improve water-electrolyte metabolism during exposure to hypoxia.