^（99）Tc^(m)－d，l－HMPAO分解动力学及稳定方法的研究

STUDIES ON THE KINETICS OF ^(99)Tc^(m)-d,l-HMPAO DECOMPOSITION AND THE METHOD OF STABILIZATION

报道了用国产药盒制备的￣（９９）Ｔｃ￣ｍ－ｄ，ｌ－ＨＭＰＡＯ（ＬＣ）分解动力学的研究。结果表明：ＬＣ分解反应为一级反应。在实验条件为２０℃、放射性浓度为１８５ＭＢｑ／ｍｌ、ｐＨ为７．０时，ＬＣ的分解速度常数ｋ为０．０１７±０．０７ｈ￣（－１）。ＬＣ溶液的稳定性与ｐＨ、放射性浓度及温度有关。在室温下，加入１ｍｍｏｌ／ｌ龙胆酸作稳定剂时，７４０ＭＢｑ／ｍｌ的ＬＣ能稳定３ｈ，放化纯度大于８０％。

The kinetics of ￣(99)Tc￣m-d,l-HMPAO decomposition is studied using hon1e kits. The resultsshow that ￣(99)Tc￣m-d,l-HMPAO decomposition is a first-order reaction, The decomposition con-stant k is found to be 0.017±0. 007h￣(-1) under the experimental conditions of 20℃,185MBq/ml,pH 7.0.The stability of ￣(99)Tc￣m-d,l-HMPAO is affected not only by pH and radioactive concen-tration, but also by temperature. Using gentisic acid as a stabilizer,740MBq/ml of ￣(99)Tc￣m-d,l-HMPAO can be stabilized for 3h with the radiochemical purity above 80%.