血清酸性铁蛋白测定对肿瘤诊断价值的探讨

Evaluation Of serum acidic isoferritin for the diagnosis of tumour

本文报道了用人酸性铁蛋白放射免疫分析检测８种肿瘤共２６７例患者血清，发现酸性铁蛋白是较好的肿瘤诊断检测指标，尤其适合于肝癌诊断，推荐与ＡＦＰ进行平行试验。诊断试验的评价结果表明，酸性铁蛋白检测对肝癌诊断的特异度和准确度最高；敏感度以肝癌、肺癌最高、胃癌最低；阳性、阴性结果预测值和假阳性率、假阴性率分析均以肝癌组为优；说明酸性铁蛋白对肝癌有一定的特异性，是肝癌较特异的病理学标志物，值得开发和应用。

levated serum acidic isoferritin(AIF)level was observed in 8 groups of cancers patients with RIA. AIF was better than ferritin for the diagnosis of tumour,the best sensitivity and specificity was obtained in hepatoma.These findings suggested that the increased AIF in the serum of patients is produced by the tumor. Therefore,serum AIF level could be used for the diagnosis of hepatoma.