全合成海南粗榧新碱的研究

Studies on Total Synthesis of Hainanensine

海南粗榧新碱是从海南粗榧和三尖杉植物中分离得到的一种抗癌有效成份。首次设计并完成了一条以胡椒醛和Ｌ－（＋）谷氨酸为起始原料，经１４步反应，全合成海南新碱的路线，提出了由化合物（１３）在酸性条件下生成海南新碱的反应机理。

Hainanensine,a new antitumor constitutent alkaloid produced by cephlotaxus hainanen-sis Li and C.fOrtuei, has been synthesized first in 14 steps from L-(+)glutamic acid and peperonal.A possible mechanism of rearrangment for cyclization of 2-oxo-1-(5,8,9,10-tetrahydro-6H-1,3-dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-11-yl)-propanone to give hainanesine isdiseribed.