上皮性卵巢癌患者雌、孕激素受体与病理特征的关系

Histopathologic relation between estrogen and progesterone receptors in epithelial ovarian carcinoma

采用酶联亲和组化法测定了３０例上皮性卵巢癌的雌激素受体（ＥｓｔｒｏｇｅｎＲｅｃｅｐｔｏｒ简写为ＥＲ）和孕激素受体（ＰｒｏｇｅｓｔｅｒｏｎｅＲｅｃｅｐｔｏｒ简写为ＰｇＲ），同时对肿瘤组织进行了病理学分析。结果发现：ＰｇＲ阳性率和肿瘤病理分级、坏死情况、纤维化程度、核分裂相及瘤巨细胞多少有关；ＥＲ仅与肿瘤纤维化程度有关。提示：上皮性卵巢癌的ＥＲ、ＰｇＲ尤其是ＰｇＲ与肿瘤的病理特征有一定关系，在一定程度上能够反映肿瘤的恶性行为及机体的防御反应，因此，ＥＲ、ＰｇＲ是肿瘤细胞的一种特征，也可做为肿瘤分化的一项指标。

Thirty primary epithelial ovarian carcinomas were analyzed with enzyme linking affinity histochemistry methed for estrogen and progesterone receptors.The results were compared with the multiple histologic parameters(grade,necrosis,lymphOcyte infiItration,mitosis,tumor giant cell).The results showed that the estrogen and the progesterone receptors of epithelial ovarian cancer were related to the grade,mitoses,fibrosis,tumor giant cell(PgR),but not to necrosis and lymphocyte infiltration.With the exception of these relations,the estrogen and progesterone receptors of ovarian cancer appear independent of all the histologic parameters.