氯氮平、氯丙嗪治疗Ⅰ型精神分裂症疗效及副反应观察

A comparative study of the clinical effect of clozapine and chlorpromazine on schizophrenia type Ⅰ

氯氮平组治疗Ⅰ型精神分裂症患者４０例，氯丙嗪组３６例，并对疗效和副反应进行对照研究。症状演变用ＳＡＮＳ及ＳＡＰＳ评定；副反应用ＴＥＳＳ评定。结果氯氮平对Ⅰ型精神分裂症的临床疗效优于氯丙嗪（Ｐ＜０．０５），复发率明显小于氯丙嗪，副反应各具特征。提示：氯氮平对Ⅰ型精神分裂症长期维持治疗安全有效。

A comparatve study was carried out on the therapeutic effects and the adverse reactions of the two antipsychotic drugs,clozapine and chlorpromazine on 76 females with schizophrenia type Ⅰ(40 treated with clozapine,and 36 with chlorpromazine).Symptomatic changes were tested with SANS and SAPS,and side effects with TESS,The patients were followed up for 1～3 years.The results showed that the clinical effect of clozapine was better than that of chlorpromazine on schizophrenia type Ⅰ.Its recurrent rate was lower than that of chlorpromazine's and the side effects of the two drugs were different.It is concluded that clozapine is safe and effective for schizophrenia type Ⅰ.The pathophysiological meehanism of the genesis of schizophrenia type Ⅰ has been discussed with a review of the relevant literatures.