大剂量抗癌药经动脉灌注化疗对胃粘膜的影响

STUDY OF THE EFFECT OF GASTRIC MUCOSA BY PERFUSION CHEMOTHERAPY WITH LARGE DOSE OF ANTINEOPLASTIC DRUGS

为探讨动脉灌注大剂量抗癌药对胃粘膜的影响，作者对７３例病人在灌注抗癌药前后行胃镜及胃粘膜病理检查，结果动脉化疗组消化道反应比静脉化疗组明显降低，统计学处理具有非常显著意义（Ｐ＜０．０１）。而化疗前后的镜下胃粘膜改变及病理组织学检查结果均无统计学意义（Ｐ＞０．０５）。动脉灌注化疗对中晚期恶性肿瘤患者无疑是一种安全有效的治疗方法，只要操作得当及预防治疗得力，即可防止或减少胃肠粘膜损害的发生。

We studied the effect of gastric mucosa after artery perfusion chemotherapywith large dose of antineoplastic drugs.Seventy-three cases were examinated by gastroscopyand histological examination before and after artery perfusion.The results show that the re-action of digestive tract after the artery perfusion chemotherapy is lower than that in the ve-nous perfusion(P<0.01 ).The clinical assessment revealed no significant differences in boththe change of gastric mucosa and the result of histological examination(P>0.05 ).Arteryperfusion chemotherapy is a safe and effective treatment method.