黄连素对小鼠实验性血栓形成的影响

TBE EFFECTS OF BERBERINE ON EXPERIMENTAL MICE THROMBOSIS

雄性小白鼠５６只，分４组，每组１４只。花生四烯酸（ＡＡ）组，于尾静脉注入ＡＡ０．５ｍｇ；黄连素＋ＡＡ组，灌喂黄连素０．５ｍｇ（２０ｍｇ／ｋｇ）；阿司匹林＋ＡＡ组，灌喂阿司匹林０．５ｍｇ（２Ｏｍｇ／ｋｇ）；生理盐水＋ＡＡ组，灌喂生理盐水０．５ｍｌ。每日１次，连续三日后尾静脉注射ＡＡ０．５ｍｇ。以上分期分批处死。见ＡＡ组心、肺出现血小板血栓者１３只、１４只，占９２．９％～１００％，黄连素＋ＡＡ组为５只，占３５．７％，与ＡＡ组相比，Ｐ＜０．００５；阿司匹林＋ＡＡ组为６只，占３２．９％，与黄连素＋ＡＡ组相比，Ｐ＞０．５，无明显差别。故认为黄连素与阿司匹林相似，也对ＡＡ所致的血小板血栓有抑制作用，值得进一步研究并于临床应用。

Fifty-six male mice were divided into four groups each of which consists of14;①the arachidonic acid(AA)group,②the berberine+AA group,③the aspirin+AAgroup,④the normal saline+AA group.The results;The platelets thrombus were respective-ly found 13 mice(95%)in the AA group,5 mice(36%)in the berberine+AA group(P<0.005,compared with the AA group)and 6 mice(43%)in the aspirin+AA group(P<0.005,compared with the AA group). The results suggest that the berberin and the aspirinhave the similar function of inhibiting the platelets thrombosis.