重症肝炎并自发性腹膜炎时肠道加用灭滴灵的疗效观察

TREATMENT OBSERVATION OF USING METRONIDAZONE ENEMA IN SEVERE HEPATITIS ACCOMPANING OF SPONTANOUS PERITONITIS

对３４例重症肝炎并自发性腹膜炎的住院病人，采用氨苄青霉素静注加灭滴灵肛门滴注和单用氨苄青霉素静注两种措施进行抗感染治疗。结果显示：腹痛、腹部压痛的消失率及腹水白细胞降至正常率，前者优于后者（Ｐ＜０．０１及Ｐ＜０．０５）；病情的改善也以前者为著（Ｐ＜０．０５）。由此提示肛门滴注灭滴灵，能有效地阻止肠源性腹膜炎，且对肝脏的损伤作用小。

The thirty-four patients with severe hepatitis accompaning of spontaneousperitonitis were treated with ampicillin intravenous injection and metronidazone enema, andampicillin only respectivily. The results demonastrated that the former were superior in los-ing abdominal pain and tenderness and decreasing the white blood cells in ascites to the latter(P<0. 01 and P<0.05).It indicated that metronidazone enema could prevent enterogenousperitonitis and have little demange to liver.