冠心病、高血压病患者血清丙二醛及抗氧化酶类含量改变的研究

STUDIES ON THE CHANGES OF SERUM LEVELS OFMALONDIALDEHYDE AND SOME ANTIOXIDASES IN PATIENTS WITH CORONARY HEART DISEASE AND HYPERTENSION

本文观察了３６例冠心病患者，２２例高血压病患者血清丙二醛（ｍａｌｏｎｄｉａｌｄｅｈｙｄｅ，ＭＤＡ）、总超氧化物岐化酶（Ｔ－ＳＯＤ）、锰－超氧比物岐化酶（Ｍｎ－ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）水平，并与２５例正常人进行对照。结果发现，两组病人ＭＤＡ均较正常人增高，Ｔ－ＳＯＤ、Ｍｎ－ＳＯＤ均较正常人降低，ＭＤＡ与血糖呈正相关。冠心病组ＧＳＨ－ｐｘ与ＨＤＬ２呈正相关。提示二组病人机体存在过氧化损伤。此种变化在动脉粥样硬化发病中可能起一定作用。

The levels of serum malondialdehyde(MDA),T-SOD,Mn-SOD,GSH-pxwere observed in 36 patients with coronary heart disease(CHD),22 hypertension and 25 no-mal subjects. The results showed that the means of serum MDA were significantly higher inthe patients with CHD(P<0.01)and hypertension (P<0.01)AND T-SOD,Mn-SOD werelower in them(P<0. 05).there were a positive relation between MDA and blood glucose inunit CHD and hypertension and between GSH-px and HDL2 in the patients with CHD. Theresults suggest that there is a lipoperoxidative damage in patients with CHD and hyperten-sion, which has some efffcts in development of atherosclerosis.