原发性高血压与遗传因素的关系──配对病例对照研究

^RELATION BETWEEN ESSENTIAL HYPERTENSION AND HERIDITARY EFFECT──A CASE-CONTROL STUDY

本文通过对１７５例先证者与１７５例对照的家系调查，探讨了遗传因素在原发性高血压发病中的作用。发现先证者家系中有高血压家族史比例显著高于对照组，两者差异十分显著。父母高血压病史是高血压发病的重要危险因素，其中母亲高血压病史危险性更高。高血压的遗传度为５８．００％±５．４６％。提示在目前开展的高血压防治工作中，因充分重视遗传因素的作用，对有高血压家族史的人应密切注意血压改变及早期症状，尽早采取措施。

In order to explore the heriditary effect and pattern of essential hypertension(EH),the family history of 175 cases with EH and 175 matched controls were investigated.The result indicated that essential hypertension had aggregation in families.The incidence ofhypertension among the first degree relatives in the studied group was 3.8 times higher thanthe controls. The hypertention heritability was 58±5. 46%. The result showed that heritabil-ity played an important role in the development of EH. The preventive measures against thepersons with family history of EH may be effective.