老年糖尿病肠病患者血小板功能、血栓素B_2及6－酮－前列腺素F_（1α）的变化

EVALUATION OF CIRCULATING PLATELET FUNCTION,TXB2 AND 6-KFTO-PGF1α IN DIABETIC ENTEROPATHY IN FHE AGED DIABTICS

对１８例老年糖尿病肠病患者和２２例糖尿病无肠病者的血小板聚集、血栓素Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）进行测定，并且与健康老年人比较。结果表明：肠病组血小板聚集率和肠病组、无肠病组血浆ＴＸＢ２、ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值均明显高于健康人组（Ｐ＜０．０１），而６－ｋｅｔｏ－ＰＧＦ１α则明显降低（Ｐ＜０．０１）。肠病组血小板聚集率、ＴＸＢ２及ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值变化较无肠病组更为明显（Ｐ＜０．０１）。这提示血小板功能亢进和血栓素Ａ２（ＴＸＡ２）与前列环素（ＰＧＩ２）间平衡失调可能在老年糖尿病肠病的发病过程中起着一定作用。

Maximum platelet aggreation ratio(MAR),plasma thromboxane B2(TXB2)and 6-keto-prostaglandin F1α(6-keto-PGF1α)were studied in 18 patients with diabetic en-teropathy(DE),22 patients with diabetes mellitus without enteropathy(DM)and 38 healthyold persons as contro It was found that TXB2 and TXB2/6-keto-PGF1α ratio were higher,6-keto-PGF1α was lower in DE and DM than that in the control (P<0. 01),The MAR was sig-nificantly increased in DE ( P < 0. 01 ).The increasement of MAR ,TXB2 and TXB2/6-keto-PGF1α were obvious higher in DE compared with that in DM.It was suggested that theplatelet hyperfunction and the serious imbalance between TXA2 and PGI2 might contribute toand ischemia change, which might cause diabteic enteropathy.