慢性胃炎、消化性溃疡及胃癌患者血清及组织中酸溶性蛋白的测定

Determination of the Serum and Tissue Acid Soluble Protein in the Patients with Chronic Gastritis,Pepic Ulcer and Gastric Cancer

人体血清酸溶性蛋白（ＡＳＰ）是一种复合蛋白群。在急性炎症、肿瘤时，血清ＡＳＰ增高。但病变组织中ＡＳＰ的测定及血与组织中ＡＳＰ的关系尚未见报道。本文对１１５例慢性浅表性胃炎（单纯型），８４例萎缩性胃炎，４４例胃、十二指肠球部溃疡（活动期），４２例胃癌血清及病变组织中ＡＳＰ含量进行了测定。结果示消化性溃疡与胃癌患者血清ＡＳＰ含量均高于慢性浅表性胃炎（Ｐ＜０．０５，Ｐ＜０．０１），而胃癌患者血清ＡＳＰ水平又高于消化性溃疡，慢性浅表性胃炎与萎缩性胃炎血清ＡＳＰ水平比较差异光显著性。上述各类疾病病变组织中ＡＳＰ含量比较差异无显著性。四种疾病血清及组织中ＡＳＰ水平无相关性。提示血清ＡＳＰ可作为一种肿瘤标志物。血清ＡＳＰ的升高可能与病变是否刺激肝脏有关。

The serum and tissue concentration of acid soluble protein (ASP) was determined in 115cases with chronic superficial gastritis (CSG), 84 cases with chronic atrophic gastritis(CAG), 44 cases with peptic ulcer (PU) and 42 cases with gastric cancer. The resultshowed that the concentration of serum ASP was significantly higher in PU and gastric cancer than that in CSG (P<0.05,P<0.01).The level of serum ASP was higher in the gastriccancer than in PU, but in patients with CAG, there was no statistical difference comparedwith CSG group (P>0.05).The difference was not significant in the level of tissue ASP ofthe above-mentioned various diseases. No correlation was found between the ASP level ofthe serum and that of the tissues in four diseases.