热损伤对亚硝基肌氨酸乙酯诱发小鼠前胃癌变过程的影响

Effect of Thermal Injury on the Carcinogenesis in Mice Treated with N-Nitrososarcosineethylester

以６５℃热水灌喂ＮＩＨ小鼠１３周后，７８．５％的小鼠前胃粘膜鳞状上皮发生乳头状增生，固有膜血管充血和炎性细胞浸润等炎性粘膜改变。灌喂热水加亚硝基肌氨酸乙酯组，８５．７１％的小鼠前胃上皮发生癌变，明显高于对照组癌变率５３．５７％（Ｐ＜０．０１）。结果表明，热损伤可引起小鼠前胃粘膜炎症性改变，而炎症造成的粘膜损伤又增加了粘膜上皮对致癌物的敏感性。慢性热损伤可能是促癌因素之一。

Chronic oral administration of hot water (65℃) was carried out in 28 NIH mice for 13weeks. Mucosal inflammation of the mouse forestomach was observed in 22 mice (78. 5%).Squamous cell carcinoma of the forestomach was detected in 85. 71% of the mice treated withcombination of hot water and N-Nitrososarcosineethylester (NSEE),in contrast to 53. 57%(P<0.01) of mice treated with NSEE alone. Thus,it indicates that chronic thermal injury byhot water could creat inflammatory lesion,and that a weakened epithelium induced by inflammatory lesion might increase the sensitivity to carcinogens. Therefore,thermal injury is oneof the promoting factors for development of cancer.