摘要
我们通过测定Ｐ３８８／ＡＤＲ及Ｌ１２１０／ＤＤＰ抗药株ＧＳＴ活性表明：Ｐ３８８／ＡＤＲ耐药株ＧＳＴ活性分别为敏感株的１．３６（耐药８．７倍）和１．７３倍（耐药４４．４倍），顺铂耐药株ＧＳＴ活性为敏感株的１．２６倍，ＶＰ使耐药株ＧＳＴ活性增加１．１９倍。表明阿霉素耐药与ＧＳＴ活性增强有关。
The level of glutathione transferase activity was determined in the whole cell extracts. It showed a 1. 36 and 1. 73-fold increase in GST enzymic activity in Adr-resistant P388 ascites cells (8. 7 and 44. 4-fold) (P<0. 01). whereas the L1210/DDP (cis-platinum resistant lines) increased 1. 26-fold in enzyme activity in resistant cells. It also showed a 1. 19-fold increase in GST activity in P388/ADR reversed by verapamil.
出处
《河南肿瘤学杂志》
1994年第4期255-256,共2页
Henan Journal of Oncology
