胃腺癌和癌旁腺体形态改变的病理学观察

Pathological Study of Morphologic Changes in Adenocarcinoma and Adjacent Mucosa of Gaster

我们对１０７例胃腺癌和癌旁腺体的形态改变，结合粘液组织化学和免疫酶组织化学的方法进行了观察，发现不同性质的腺体扩张和组织学类型有关。单纯性腺体扩张见于各种类型的腺癌；异型性腺体扩张多见于管状腺癌。尤其早期管状腺癌出现各级、多量异型腺体扩张，并与管状腺癌的腺体交叉，有向管状腺癌由轻度到重度异型增生上皮过渡的形态。异型性腺体扩张的组织结构、细胞形态、粘液组织化学和免疫酶组织化学都与管状腺癌相一致，只是程度的差异。

Using mucohistochemical and immunohistochemical methods, morphologic changes in adenocarcinoma and adjacent mucosa of gaster from 107 cases were observed. It was found that glandular expansion of different nature was related to histopathologic types. Simple glandular expansion appeared in adenocarcinoma of different types whereas dysplastic glandular expansion was seen in tubular adenocarcinoma. Study shows that early tubular adenocarcinoma can be closely related to dysplatic glandular expansion. Particularly, tubular adenocarcinoma undergoes a transitional period from light type to the course of the heavy dysplatic type. The pathologic histology, mucohistochemistry and immunohistochemistry of the dysplatic glandular expansion are similar to tubular ademocarcinoma only with slight difference of degree.