二甲苯胺噻唑在绵羊脑脊液中的药物动力学研究

Study on Pharmacokinetics of Xylazole in Sheep CSF

以内标气相色谱法为定量手段．研究二甲苯胺噻唑在绵羊脑脊液（ＣＳＦ）中的药动力学．实验结果表明，绵羊肌注二甲苯胺噻唑（２．５ｍｇ／ｍｌ）后，ＣＳＦ药物经时特征主要符合一级吸收单室开放模型．部分符合一级吸收双室开放模型，其主要药动学参数：吸收半衰期为３．８６８±１．４５２ｍｉｎ，消除半衰期为１４０．３３８±１１０．０３８ｍｉｎ，ＣＳＦ药浓度达峰时间为１７．６３７±５．８５０ｍｉｎ，ＣＳＦ药峰浓度为０．０９６３±０．０２６０μｇ／ｍｌ，曲线下面积为１２．１３１８±２．２８３４μｇ／ｍｌ．ｍｉｎ。

Pharmacokinetic prouss of xylazole in sheep CSF is studied by internal standard gas-chroma to graphy.Pharmacokinetic results indicated that xylazole given im at a dose rate of 2.5 mg/kd its concentration time Course is mainly accorded to fitting one compartment dpen model and partly conformed to following a two compartment open model with first order absorption.The primary pharmacokinetic parameters ars as follows. Absorption half-time is 3.868±1.452min Elimination half-time is 81.069±30.631min。peak tine is 17.637±5.850min.Peak concentratiom is 0.0963±0.0260μg/ml.The area under the curre is 12.1318±2.2834μg/ml min.