二甲苯胺噻唑在绵羊血液中的药物动力学研究

Studies o Pharmacorinetics of xylzyole in sheep

给绵羊肌注二甲苯胺噻唑（２．５ｍｇ／ｋｇ）用内标气相色谱法测出其不同时间的血药浓度，药动学分析结果表明，血药经时特征主要符合一级吸收单室开放模型，部分符合一级吸收双室开放模型．其主要药动学参数：吸收半衰期为９．２８２±２．５７９ｍｉｎ，消除半衰期为８１．０６９±３０．６３１ｍｉｎ，达峰时间为２９．１２０±５．７７１ｍｉｎ，峰浓度为０．２７０５±０．１３０９μｇ／ｍｌ，药时曲线下面积为３０．５３２±１１．５００８μｇ／ｍｌ·ｍｉｎ．

Phcrmacokinetic Process of xylazole in sheepo serum is studied byinternal standard gas Chromatography.Pharmacokmefic results indicotesthat Xylazole given im at a dose Tate if 2.5mg/kg,its concentrationtime course is mainly accorded to fitting one Compartment openinodeland partly conformed to following a two compartment open model withfirst oredr absorption.The primary pharmacokinetic parameters are asfollows Absorption half-time is 9.282 ± 2.579min,Eliminafion halftimeis 81.069±30.631min peak time is 29.120±5.771min,Peak Concentration is 0.2705± 0.1309μg/ml.The area under the curve is 30.5322±11.5008μg/ml.min