原发性支气管肺癌患者血清催乳素水平及临床意义

Serum Prolactin Level of Bronchogenic Carcinoma and Its Clinical significance

采用放射免疫分析法测定了２６例原发性支气管肺癌患者血清催乳素，并与２６例健康献血员进行了比较。肺癌组血清浓度为２１．４±１１．４８μｇ／Ｌ，对照组为１３．７５±５．４４μｇ／Ｌ，两组之间差异有高度显著性（Ｐ＜０．０１）．肺癌组有９例（３４．６％）血清催乳素浓度高于正常，认为催乳素具有作为肺癌辅助诊断指标的价值，其特异性为９２．３１％，敏感性为３４．６％。本文还初步观察了６例肺癌患者治疗前后血清催乳素浓度的变化，认为血清催乳素可作为疗效考核和预防的好指标。

Serum prolactin levels were studied in 26 untreated patients of bronchogenic carcioma and 26 healthy blood donors by radioimmunoassay. The former's level 21.4±11.48;μg/L,and the latter's 13.76±5.44 μg/L showing a big difference(P<0.01).In 9 of the 26 carcinoma patients the serum prolactin level was >20μg/L.Therefore,its specificity was 92.3%(24/26) and its sensitivity 34.6%(9/26). The data show that the serum prolactin level can be used as a marker of diagnosis of lung cancer.The comparison of serum prolactin before and after treatment of 6 cases of lung cancer was carried out. The preliminary results suggested that the serum prolactin level can be used as index for the evaluation of treatment and prognosis,and the index may even be more important than its diagnostic value. It may especially play a role of surveillance in the sytematic observation of the course of disease for the patients who received an operation.