摘要
通过组织胺(Ht)对小鼠Lewis肺癌(LLC)生长和转移的抑制作用实验研究,现在了Ht对小鼠LLC癌细胞酸性磷酸酶(ACP)活性的影响以及LLC的病理形态的改变,结果发现Ht能明显抑制LLC细胞ACP活性。组织学观察可见Ht处理后LLC中心坏死率高,且中心坏死区大,并出现显著的周边坏死。而这种坏死在对照组LLC组织中未曾发生。电镜观察发现Ht处理后小鼠LLC细胞出现不同程度的变性,以致坏死。表明Ht对小鼠LLC具有直接的破坏作用。
Our work indicated that histamine significantly decreased acid phoshatase(ACP) staining activity of Lewis lung carcinoma(LLC) cells. A Histological study showed that the LLC-bearing mice treated with histamine had a modified histological structure of tumours. This consisted mostly of the presence of bands and foci of necrotic. These lesions were observed at the periphery as well as in centralpart of tumours. This resembled acute necrosis associated or not with a haemorrhagic phenomenon, No celluar infiltrates surrounded the necrogic areas. Ultrastructural changes included the swelling of mitochondria; the splitting of mitochondria crests; the breakdown and even total disappearence of tumour cells. These distrutive changes were rarely observed in the control tumour cells and even the organells in these cells were relatively intact. We concluded that direct actions involved in anti-tumour mechanism of histamine.
关键词
组胺
肺肿瘤
药物疗法
癌
病理学
histamine/TU
lung neoplasms/TH
mice
animals
laboratory