慢性肝病中HBV／HCV双重感染的血清学调查及意义

Serological Investigation and Significance of HBV/HCV Double Infection in the Patients with Chronic Hepatitis

采用酶免疫法检测１０４例慢性肝病和１６４例献血员丙型肝炎抗体（抗－ＨＣＶ），阳性率分别为１８．３％（１９／１０４）、１．８％（３／１６４）；慢性肝病中ＨＢＶ／ＨＣＶ双重感染１３例。ＨＢＶ／ＨＣＶ双重感染组（Ｂ组）与单纯丙型肝炎组（Ａ组）谷丙转氨酶（ＡＬＴ）差异无显著性（Ｐ＞０．０５）。与单纯慢性乙型肝炎组（Ｃ组）ＡＬＴ差异有显著性（Ｐ＜０．０５）；３组间血清总胆红素差异有显著性（Ｐ＜０．０５）。本文结果表明：ＨＢＶ／ＨＣＶ双重感染可加重肝脏损害，多数病例未见ＨＢＶ与ＨＣＶ干扰现象；正常人群也存在丙型肝炎隐性感染。

Anti-HCV was determined in the sera of 104 cases of chronic hepatitis and 164 blood doners by EIA diagnostic system. The positive rate was 18.3%(19/104)and 1.8%(3/164) respectively, among the 19 cases ,13 cases were HBV/HCV double infection. The difference of average level of total bilirubin was statistically significant(P<0.05) among the group B with HBV/HCV double infection, the group A with chronic hepatitis of single HCV infection and the group C with chronic hepatitis of single HBV infection. The difference of average level of ALT were statistically significant(P<0.05)between the group B and the group C, but not statistically significant between the group B and the group A. These results indicate that HBV/HCV double infection may accelerate the damage of liver tissue, there wasn't evidence of interference of replication of HBV by HCV infection.