摘要
采用脑干听觉诱发电位（ＡＢＲ）测试１４例新生儿高胆红素血症（高胆组）和１７例正常儿对照显示：高胆组１４例中ＡＢＲ异常１０例（７１．４％），以Ⅰ波延长或缺失居首，Ⅴ波异常次之，４耳Ⅰ～Ⅴ波延长，２／３病例急性期ＡＢＲ阈值增高，经治疗多数恢复正常。结论：新生儿高胆红素血症可致脑干、听功能损害，且与血清总胆红素及未结合胆红素升高浓度关系密切。ＡＢＲ为新生儿高胆红素血症的神经系统及听力损害提供了客观依据。
Auditory brainstem response(ABR)was used to examine 14 newborns with hyperbilirubinemia in comparson with 17 normal persons.As a result 10 of the 14 cases showed abnormal ABR(71.4%)prolonged wave Ⅰaccounting for the first and,abnormal wave Ⅴfor the second.Prolonged waves Ⅰ-Ⅴoccurred in 4 ears.2/3 of the patients with increased threshold value in the acute period recovered after treatment.In conclusion newborn hyperbilirubinemia may injure brainstem and auditory function,and be related to higher concentration of tatol-bilirubin and free-bilirubin in serum.ABR may provide an objective basis for barrier of nervous system and hearing in newborn hyperbilirubinemia.
关键词
高胆红素血症
脑干
听觉
诱发电位
hyperbilirubinemia
infant,newborn
brain stem
audiometry
