摘要
用电子显微镜和组织化学染色证实经肾动脉灌注刀豆球蛋白Ａ（Ｃｏｎ－Ａ）诱导的淋巴因子可造成大鼠肾小球上皮细胞多阴离子的丢失和足突融合。这一改变符合微小病变型肾病综合征的基本病理变化，从而提示被激活的抑制性Ｔ细胞参予了单纯性肾病的发病机制。
Infused into the renal artery of rats,lymphokines produced from Con-A activated lymphocytes can cause extensive fusion of the epithelial foot processes and reduction of charge of the glomerular basement membrane of rat kidneys.
关键词
刀豆球蛋白A
肾小球疾病
T细胞
concanavalin A/TO
perfusion,regional
nephrosis,lipoid/ET
suppressor cells/DE
rats
animals,laboratory
