摘要
对阿普拉霉素在黑山羊体内的代谢动力学进行了初步分析.一次静脉推注阿普拉霉素6000u/kg·w,给药后4h内按不同时间采血,用抗菌素管碟法测定血药浓度,3只黑山羊的试验结果表明,血药浓度时间曲线符合二室开放模型,不符合单室开放模型,其药物代谢动力学参数如下:消除速率常数(β)0.989±0.002(h-1);初始浓度(B)14.130±2.056(U/100mL);消除半衰期(T1/2β)0.696±0.006(h);维持有效血药浓度时间TCP4.06±0.14(h);表观分布容积(Vd)429.13±64.63(100mL/mg);廓清率(CLB)424.67±63.66(100mL/kg·h).
h after 6 000 U/kg· w of Apramycin was injected intravenously,blood wascollected at certain time. Blood drug concentration was determined with tube-plate of antibi-otic. The results showed that time curve of blood drug concentration in goat corresponded totwo -compartment model,but not to one-compartment model.The pharmacokinetic parame-ters read as follows :the clearance constant(β)was 0.989 ± 0.002(h-1);The preliminaryconcentration(B)was l4.13 ±2.056(U/100 mL);Clearance half-life( T1/2β)was 0.696±O.006(h);Time of effective blood drug concentration(TCP) was 4.06±0.14(h);Appa-rent distributive volume(Vd)was 429.13±64.63(100 mL/kg);Clearance ratio(CLB) was424.67±63.66(100 mL/kg·h)
关键词
抗菌素
山羊
代谢
阿普拉霉素
antibiotics
goats
metabolism
kinetic analysis/apramycin