摘要
以超微结构、线粒体形态计量及ＬＤＨ，ＳＯＤ活性为依据，探讨３，４－二羟基苯乙酮（ＤＨＡＰ）对家兔缺血－再灌心肌细胞的影响。结果表明：ＤＨＡＰ组缺血－再灌心肌细胞的损伤、ＬＤＨ丢失及ＳＯＤ活性下降的程度均明显低于未用药组。提示该药物对缺血－再灌心肌有保护作用。
he ultrastructural changes together with the activities of LDH and SOD in myocardial
tissues were analysed to evaluate the protective effects of DHAP on myocardial
ischemia-reperfusion injury of rabbits.The results showed that DHAP could mitigate the
myocardialuItrastructural injury and decrease the loss of LDH and the activity drop of SOD. It
wassuggested that DHAP had the protective effects on myocardial ischemia-reperfusion injury.
出处
《湖南医科大学学报》
CSCD
1994年第1期15-17,32,共4页
Bulletin of Hunan Medical University
基金
七五攻关
关键词
冠状动脉疾病
二羟基苯乙酮
心肌
coronary disease
disease model,
animal
dihydroxyacetophenone
my-ocardium
mitochondria, heart
stereology
lactate
dehydrogenase
superoxide dismu-tase
rabbits①Department of Bioehemistry,Hunan Medical
University②Laboratory of Electronic Microscope,Hum
