膀胱癌患者细胞免疫功能检测及其临床意义探讨

OBSERVATION OF CELLULAR IMMUNE FUNCTION IN PATIENTS WITH BLADDER CARCINOMA

报道３０例膀胱癌患者和３４例正常人的细胞免疫功能检测结果。膀胱癌患者外周血ＩＬ－２活性、干扰素水平均显著低于正常人。患者ＮＫ活性、ＩＬ－２受体表达均显著低于正常人。患者ＯＫＴ３＋细胞比例下降，ＯＫＴ８＋细胞比例升高，ＯＫＴ４＋细胞无明显改变；ＯＫＴ４／ＯＫＴ８细胞比值减小。患者ＮＫ活性与ＩＬ－２活性及干扰素水平呈直线正相关；ＩＬ－２活性与Ｔ４细胞及Ｔ４／Ｔ８细胞比值呈直线正相关。

In this paper,the results of cellular immunologic function tests in 30 patients with blad-der carcinoma and 34 normal donors were reported.The activity of IL-2 and IFNr in patientswith bladder carcinoma was significantly lower as compared with normal donors,but those innon-invasive patients did not differ from invasive. The NK activity and expression of IL-2R inpatients were significantly lower than that in normal donors.Also,the proportion of OKT3 Tcells and the ratio of OKT4/OKT8 in patients were lower,but the percentage of OKT8 cellsin patients was higher than those in normal donors,The rate of OKT4 cells in patients didnot differ from normal donors,There was a significant position correlation between IL-2 ac-tivity,IFNr level and NK activity in patients. In the same way,the position correlation ap-peared between the rate of OKT4 cells,the ratio of T4/T8 and IL-2 activity.