卡托普利对阿霉素心脏毒性作用的影响

EFFECTS OF CAPTOPRIL ON ACUTE ADRIAMYCIN CAKDIOTOXICITY

用离体大鼠心脏灌流模型观察了卡托普利（ｃａｐｔｏｐｒｉｌ，ＣＡＰ）对阿霉素（ａｄｒｉａｍｙｃｉｎ，ＡＤＭ）急性心肌毒性作用的影响。结果表明，ＡＤＭ（６ｍｇ／Ｌ）灌注能造成心肌收缩力的严重损害，冠脉灌注压的明显升高和心肌丙二醛含量的增加；治疗剂量的ＣＡＰ（４０ｍｇ／Ｌ）并不能保护心肌，反而加重了ＡＤＭ对心脏的毒性作用。作者认为，在防治ＡＤＭ所致的心功能不全时应慎用ＣＡＰ。

he acute effects of adriamycin (ADM)on force of contraction,coronary perfusion andcardiac malondialdehyde(MDA)content were measured in isolated rat hearts Derfused atconstant flow, Experimental hearts were perfused for 60min with Kreb- Hesenleit solutioncontaining 6mg/L ADM. treatmental hearts were perfused with 6mg/L of ADM and 40 mg/Lof captopil. In the experimental group,contractile force steadily decreased to 2.5%±1.8(P<0. 01) of inital levels while coronary perfusion pressure steadily increased to 230±48%(P<0. 01).The cardiac MDA content increased significantly(P<0.01).These results suggest-ed that the cardiotoxicity of adriamcin might be related to lipid peroxidation,However,capto-pril,an angiotensin converting enzyme inhibitor possessing anti-free radical effect,did notprotect against the effects of adriamycin, but deteriorated the cardiac function of hearts per-fused with adriamycin,The mechanism retnains to be investigated.