摘要
应用ＰＡＰ免疫组化法检测４０例胆囊癌组织中６－Ｋｅｔｏ－ＰＧＦ＿（１α）和ＴＸＢ＿２表达。半定量分析表明：两者阳性率各分Ｓｄ为６２．５％和５２．５％；高分化腺癌高于低分化腺癌；部分阳性病例癌周上皮呈阳性，且着色有向癌组织递增现象。结果提示：部分癌组织能合成ＰＧＩ＿和ＴＸＡ＿２，且与病理类型、分化程度及癌变过程有一定关系；其ＰＧＩ＿２和ＴＸＢ＿２可能相互影响，并可能诱导癌周间质炎性细胞浸润。
he expressions
and their significances of 6-Keto -PGF1α(6KPF)and TXB2 were studiedby
immunohistochemical method in 40 cases of gallbladder carcinomas. The positive rate of6KPF
and TXB2 was 62.5%and 52.5%respectively,the positive rate of 6KPF and TXB2 washigher in
well一differentiated or infiltrated grade II of inflammatory cells adenocarcinomasthan that in
poorly一differentiated or infiltrated grade 0 of inflammatory cells adenocarcino-mas. The
positive correlations were found between the expression of 6KPF and TXB2,no significant
correlations were found among the positive rate of 6KPF,TXB2 and the clinicalfeatures. In
addition,it was discussed about the biological significance of the assays of 6KPFand TXB2 in
gallbladder carcinomas.
出处
《湖南医科大学学报》
CSCD
1994年第4期305-308,共4页
Bulletin of Hunan Medical University
关键词
胆囊肿瘤
癌
前列腺素
血栓素
免疫组织化学
gallbladder neoplasms
cancer
prostaglandins
X
thrombonane A2
immunohistochemistry
