摘要
采用免疫组化方法，结合临床病理，检测了１１例嗅神经母细胞瘤的神经特异性烯醇化酶（ＮＳＥ）、神经纤维蛋白（ＮＦ）、Ｓ－１００蛋白（Ｓ－１００）、神经胶质纤维酸性蛋白（ＧＦＡＰ）、角蛋白（Ｋｅｒａｔｉｎ）和白细胞共同抗原（ＬＣＡ）。结果显示：瘤细胞以片状、梁索状排列为特征，细胞间可见胞浆突起形成的嗜酸性纤维；ＮＳＥ，ＮＦ，Ｓ一１００阳性检出率分别为１００％、４５．５％、２７．３％，其它组化结果阴性。作者认为，ＮＳＥ对该病诊断有特异性价值，其它组化检测有助于诊断与鉴别诊断。
he Clinicopathologic and
immunohistochemical studies of 11 cases of olfactory neurob-lsatoma were made. Its
pathologic features were small tumor cells arranged in pieces or stripsand acidophilic fibrillary
which was intercytoplasmic,but rosettes of tumor tissue were foundin a few cases.
Immunohistochemistry showed that neuro一specific enolase(NSE)of 11 caseswere
positive(100%);neurofilament protein(NF)of 5 case;werepositive(45. 5%).S一100 protein(S一
100) of 3 cases were positive(27.3%),but glial fibrillary acidic protein(GFAP),keratin,leucocyte
common antigen (LCA)showed all negative. The results iridi-cate that NSE is the most useful
diagnostic feature for olfactory neuroblastoma;NF,S一100canhelp in the diagnosis of this
tumor;GEAP,Keratin LCA are beneficial in distinguishing them from other tumors.
出处
《湖南医科大学学报》
CSCD
1994年第4期302-304,共3页
Bulletin of Hunan Medical University
关键词
神经母细胞瘤
病理学
免疫组织化学
嗅神经
neuroblastoma
diagnosis,differential
pathology
immunohistochemistry
