摘要
对１７例风湿性心脏病二尖瓣狭窄患者经皮二尖瓣球囊成形术术前和术后一周分别检测血浆肾素（ＰＲＡ）、血管紧张素Ⅱ（ＡＴ－Ⅱ）和醛固酮（ＡＬＤ）。结果表明：术前ＰＲＡ，ＡＴ－Ⅱ和ＡＬＤ明显高于对照组；术后血流动力学明显改善，并伴有ＡＴ－Ⅱ和ＡＬＤ水平显著降低（Ｐ＜０．０５）。ＡＴ－Ⅱ下降与左房压下降呈弱正相关（ｒ＝０．４３ｌ）。揭示在心功能不全早期已有肾素－血管紧张素－醛固酮系统（ＲＡＡＳ）过度激活；术后，在血流动力学改善的同时，ＲＡＡＳ也有相应改变。
he levels of plasma renin(PRA),angiotensin-2(AT-2)and aldosterone(ALD)in
20healthy subjects and 17 patients with rheumatic mitral stenosis were maesured by RIA
beforeand after percutaneous balloon mitral valvuloplasty(PBMV),and the hemodynamic
changeswere recorde during PBMV. The results showed that AT-2 and ALD were significantly
lowerafter PBMV and PRA was little higher but without significance(P>0.05).The decreasedAT-2
positively correlated with the change of the left atrial pressure(r=0.431).We con-clude that
PBMV may correct the superactive renin-angiotensin-aldosterone system(RAAS)and partially
improve hemodynamics of the patients with rheumatic mitral stenosis.
出处
《湖南医科大学学报》
CSCD
1994年第5期433-435,共3页
Bulletin of Hunan Medical University
关键词
二尖瓣狭窄
球囊成形术
肾素
血管紧张素
mitral valve
stenosis
balloon dilatation
renin-angiotensin system
hemodynamics
