兔急性感染性脑水肿脑组织钙含量的改变

CHANGE OF CALCIUM IN BRAIN TISSUE DURING ACUTE INFECTION BRAIN EDEMA IN RABBITS

采用百日咳菌液右侧颈内动脉注射造成兔急性感染性脑水肿模型，测定脑组织含水量和含钙量。结果显示：注射菌液后１ｈ，右侧脑组织含水量和含钙量较对照组明显升高，并随病情发展进一步增高，两者变化呈显著正相关；左侧脑组织含水量增高前２ｈ已有明显钙聚积。提示脑组织钙聚积可能系感染性脑水肿发生、发展的重要因素之一。

he brain edma(BE)model was induced by injection of pertussis bacilli suspension(PBS)into right interanl carotid of rabbits. Normal saline was used as the control.Water andcalcium contents in the brain tissue were measured at different times after the injection ofPBS. Average water and calcium contents in the right hemispheres at one hour after the injec-tion of PBS were 81.40±1.12%and 10.87±2.15mmol/kg dry brain tissue respective-ly. They were all significantly higher than those of the controls(P<0.01 ).The water andcalcium contents increased continously as the BE developed.There was a good linear correla-tion between the calcium and water contents in the right hemishperes during the developmentof the BE(r=0.8902,P<0.01).There had been an obvious calcium accumulation in the lefthemispheres two hours before significant increment of the water content.The results suggestthat calcium accumulation in the brain tissue is one of the important pathogenic factors fordevelopment of the infection BE.