血吸虫病肝纤维化气血辨证与锌铜铁关系及抗纤方的调节作用

PELATION BETWEEN Q1-BLOOD SYNDROME AND ELEMENTS Zn,Cu AND Fe AND REGULATING ACTION OF KANG XIAN FANG IN HEPATIC FIBROSIS OF SCHISTOSOMIASIS

对１０６例日本慢性血吸虫病肝纤维化（虫肝纤）患者血清微量元素锌、铜、铁进行了检测。虫肝纤患者血清锌、铜、铁含量与正常对照组（２０例）比较均有不同程度改变。其中气虚血瘀组（４１例）以锌值下降为特征（Ｐ＜０．０５或Ｐ＜０．０１），气滞血瘀组（４３例）以铜值升高为特点（Ｐ＜０．０５或Ｐ＜０．０１），这可作为虫肝纤气血辩证的微观指标之一。对其中８２例进行了治疗，抗纤灵Ⅰ方组（３３例）锌、锌／铜、铁值显著性上升，抗纤灵Ⅱ方组（３４例）的锌含量以及铁值亦明显上升，铜值呈下降趋势，而西医常规治疗组（１５例）血清微量元素锌，铁值及锌／铜比值未见显著性差异。表明微量元素代谢障碍与血吸虫病肝纤维化的形成及中医气虚血瘀、气滞血瘀证的产生有密切关系。

The authors examined serum micro-elements Zn,Cu and Fe of 106 ptients with chromicheptic fibrosis of schistosomiasis Japonica(HFS).Those micro-elements of HFS patients,acompanied with20 persons of control group,havesome change.Zn and Fe in the qi-blood dificiency group of 41 patients in-creases obviously,Cu lowers,but in the modern medicine group(15 patients),the serum Zn,Fe amd Zn/Cuhaveno significant differency.The result shows that the dysbolism of serum micro-relements are closely relat-ed to the formation of HFS and production of qiweakness and blood stasis sydrome,and qistagnation andblood stasis syndrom.