单环非典型内酰胺的抗菌活性与化学活性关系研究

STUDIES ON THE RELATIONSHIP BETWEEN THE CHEMICAL REACTIVITY AND ANTIBACTERIAL ACTIVITY OF MONOCYCLIC NON-CLASSICAL LACTAMS

对已合成的六个单环非典型内酰胺使用量子化学的ＭＮＤＯ方法进行计算，所得结果支持作者关于化学活性是决定单环非典型内酰胺抗菌活性主要因素的设想。

Six monocycli nonclassical lactams synthesized were firstly studied by quantum chemical MNDO method.The hypothesis that the chemical reactivity dominantly determined the antibacterial activity for monocyclic nonclassical lactam antibiotics was supported by the results.