摘要
本文报道用均匀设计方法以正辛醇、氢溴酸、浓硫酸为原料合成正溴辛烷，收率为９１％；以正溴辛烷和已内酰胺，在ＫＯＨ、ＰＴＣ存在下，以甲苯作溶剂，合成１－正辛基氮杂环庚烷－２－酮，收率为９３．２％。反应条件较文献报道的温和，且收率很高。
Octylazacycloheptan-2-One is a better penetration enhancer.It was prepared by means of hexanolaction,n-Octyl bromide,KOH and phase transfer Calalysts.The reaction condition was obtained by the uniform design. The reaction mixture was heated to reflux for 7 hours. The reaction mixturewas cooled, filfered and the filfrate was concentrated to a yellow oil,Distillationofforded 21.0g(93.2%)of colorless product;b.p 170-175℃/2mmHg,
出处
《华西药学杂志》
CAS
CSCD
北大核心
1994年第1期4-6,共3页
West China Journal of Pharmaceutical Sciences
关键词
正溴辛烷
己内酰胺
合成
渗透剂
n-Bromooctane Caprolactam penetrant 1-Octylazacycloheptan-2-one
