鸡对传染性囊病疫苗免疫应答的病理形态学研究

THE PATHOMORPHOLOGICAL STUDY ON IMMUNE RESPONSE CAUSED BY INFECTIOUSBURSAL DISEASE(IBD)VACCINES

本项研究除采用巨检和病理组织学常规染色外，并应用组织化学和扫描电镜等检测手段，比较细致地观察了ＩＢＤ免疫过程中所出现的一系列形态学变化，加深了对本病的认识。研究结果阐明，在鸡群可能受ＩＢＤＶ野毒威胁的情况下，宜选用中强毒力的ＩＢＤ疫苗。受损的法氏囊组织要得到再生的两个基本条件是：１，淋巴滤泡受损后尚残存部分淋巴组织；２，囊组织再生必须在法氏囊发生生理性萎缩之前。

In addition to macroscopic inspection and conventional staining,histochemicaltechnology and scanning electron microscopy were used to observe sequential morpholog-ic changes in the IBD immune process and further our knowledge of IBD.The resultsshowed that IBD vaccines of medium virulence should preferably be selected for use in areaswhere IBD was prevalent.Whether the damaged bursa would be repaired depended on thefollowing two factors:portion of lymphoid tissue remaining after damage to the bursal lym-phfolliculi,and whether or not the regeneration of the bursa occurred before bursa involu-tion.