鸡传染性法氏囊病BK912变异株疫苗安全及效力试验

SEFETY AND BFFICACY TESTS OF INFECTIOUS BURSAL DISEASE VARIANT STRAIN VACCINE BK912

使用３批ＩＢＤ－ＢＫ９１２冻干疫苗对２０日龄在隔离器中饲养的ＳＰＦ鸡经２次点眼、口服各２０００ＴＣＩＤ５０，于二免后１４天用１００ＢＩＤ５０１０８４Ａ法氏囊囊毒攻毒，对照组１００％发病，免疫的３个组１００％保护，通过对囊指数的测定，疫苗安全，对囊无损伤。

There groups of 20-day-old SPF chicks raised in isolators were vaccinated by ocu-lar instillation and oral administration with three batches of IBD BK912 lyophilized vaccinerespectively.Booster was carried out 2 weeks later with the same method.Two weeks afterthe booster,one control group and three vaccinated groups were challenged with 100BID501084A strain.Results showed 100%morbidity for the control group and 100%protectionfor the vaccinated groups.Determination of bursa index as well as protection test reveal thatthe vaccine was safe and did no harm to the bursa.