相转移催化合成α－三氯代甲基苄原醇乙酸酯

Synthesis of α-(Trichloro Methyl)Benzyl Acetate by Phase Transfer Catalysis

阐述在合成α－三氯代甲基苄原醇乙酸酯及其主要原料α－三氯代甲基苄原醇中，采用相转移催化的基本原理和方法．考察反应时间、原料配比和催化剂用量对α－三氯代甲基苄原醇乙酸酯的影响．在反应时间为５ｈ，原料α－三氯代甲基苄原醇和乙酸酐的摩尔配比为１：１．２，无水醋酸钠催化剂和相转移催化剂（ＰＴＣ４＃）为α－三氯代甲基苄原醇摩尔数１０％时，其α－三氯代甲基苄原醇乙酸酯产率为７６％～８０％．

In synthesizing α-(Trichloro methyl)benzyl acetate and the main material-α(Trichloro methyl)benzyl alcohol,the basic principle and method of phase transfer catalysis were described.The influences of reaction time, mix ratio of raw materials,and the amount of catalyst on the yield of α-(Trichloro methyl) benzyl acetate were studied.The better reaction conditions were as follows: mix ratio(mol)of raw materials α-(Trichloro methyl) benzyl alcohol and acetic oxide, 1:1.2;reaction time,5 h.A 76%-80% weight yield ofα(Trichloro methyl) benzyl acetate was obtained when each of the phase transfer catalyst anhydrous sodium acetate and PTC 4# was in a dose of 10% α-(Trichloro methyl) benzyl alcohol mole number.The reaction mechanism was discussed as well.