摘要
本文采用ＨＰＬＣ测定人血浆中奥美拉唑的浓度、色谱柱为ＵｌｔｒａｓｐｈｅｒｅＯＤＳ４．６×２５０ｍｍ，流动相为甲醇－磷酸盐缓冲液（６０／４０），检测波长为３０２ｎｍ，流速为１ｍｌ／ｍｉｎ，血浆浓度在０．０２５～１．０ｕｇ／ｍｌ范围内线性关系良好（γ＝０．９９９８），最低检测浓度０．０２５μｇ／ｍｌ，平均回收率１００．５±１．９％。日间、日内ＲＳＤ％均＜４．１％
Omeprazole has been determined in plasma by HPLC. The column was ultrasphere ODS4.6×250mm. The mobile was methanol-phosphate baffer(60/40)with detectable wave-length 302nm and mobile rate was 1ml/min. In the range of 0.025-1.0μg/ml The concentration has good lineary(γ=0.9998).The minimum determination concentration for omeprazole in plasma was 0.025μg/ml. The mean recoveries was 100.5±1.9% with within-day and between-day RSD%<4.1%.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1994年第2期126-127,共2页
West China Journal of Pharmaceutical Sciences
