前列腺癌发病危险因素的配比病例对照研究

Risk Factors of Prostate Cancer──A Matched Case-control Study

对经病理确诊的前列腺癌２７名及１：２配对对照５４名，以问卷方式调查其饮食生活习惯、婚姻、既往前列腺疾患等对前列腺癌发病的影响。运用单因素及多因素条件ｌｏｇｉｓｔｉｃ回归分析处理资料。结果示：摄入维生素Ａ多的人群患前列腺癌的危险性低（ＲＲ＝０．９４８，Ｐ＝０．０２９），并呈剂量反应梯度关系。既往前列腺疾息增加息前列腺癌的危险性（ＲＲ＝６．３８５，ｐ＝０．０４５）．离异、丧偶、再婚者患前列腺癌的危险高于在婚者（ＲＲ＝４．３１２，ｐ＝０．０１３）。

A 1:2 matched case-control study wasused to determine the risk factors of prostate cancer. Twenty-seven cases of prostate cancer were matchedwith an equal number of other malignant tumor cases(non-urological tumor)and other urological cases(non-malignant tumor).Both study and controlgroups were the same in age,sex,race,and day of ad-mission。All of these patients were treated in the FirstAffiliated Hospital of West China University of Medi-cal Sciences. The questionnaire was used to survey theboth groups of patients. Such data as diet, lifestyle,marital status and past kistory of other prostate dis- eases were obtained. Single factor analysis and multi- ple conditional logistic regression analysis were used toestimate the relative risk(RR),95%confldence inter- val(95%CI ) and P values. Statistical analysis wasperformed using the Egret, Epilog soft ware. The re- sults were as follows:1.Increasing dietary vitamine Awas associated with a significant decrease in the risk ofprostate cancer (RR=0.948, 95%CI=0.9309 0. 9947,P=0. 029).This factor also showd dose re-sponse gradients. The relative risk was decreasingwith exposure dose increasing.2. The positive previ-ous prostate bistory, such as prostatitis and benignprostate hyperplasia, increased the risk of prostatecancer(RR=6.385, 95%CI=1. 046 38. 97,P=0. 045 ).3. Another finding in this epidemiologicalstudy was a much higher risk for prostate cancer in thewidower,divorce and remarried men(RR=4. 312,95%CI=1.367-13.6,P=0. 013); And 4.There wasno relationship between the risk of ptostate cancer anddietary fat intake,vasectomy,socioeconomic status,familial malignant tumor history , smoking and alcoholconsumption. It is suggested that previous prostateproblems and marital status may be etiologic risk fac-tors of prostate cancer, and dietary vitamine A may bea protective factor for the prostate cancer.