麻尘对肺泡巨噬细胞影响的体外研究

Effects of Jute,Ramee,Flax Dusts on Rabbit Alveolar Macrophages in Vitro

作者选择黄麻、苎麻、亚麻，采用细胞培养技术，探讨了麻尘对肺泡巨噬细胞（ＡＭ）的影响。结果表明，所用麻尘对ＡＭ均有不同程度的毒作用，导致ＡＭ存活率降低，培养液中乳酸脱氢酶、酸性磷酸酶活性上升，ＡＭ形态出现损伤性变化，但作用强度低于同浓度的石英、石棉。同时，麻尘也导致ＡＭ功能的改变，培养液中免疫球蛋白Ｇ、免疫复合物、组织胺含量增加。比较３种麻尘，其中以苎麻毒性及刺激ＡＭ分泌生物介质的能力最弱。

The effects of jute,ramee,flax dustson alveolar macrophage (AM) were observed by cellculture.The results indicated that AM could be dam-aged by all of the three kinds of dusts,The viabilitywas decreased. The activity of lactic dehydrogenase《LDH》and acid phosphatase (AcP) in the culture su-petnataht was increased. The morphology of AM wasdalnaged. But the toxicity effect of the three dusts wasless than that of SiO_2 and chrysotile asbestos(CH)in the same dosage. Meanwhile, the functions of AMwere changed.The levels of IgG,immunocomplex(IC)and histamine (HIS) were increased. As to thedegiee of toxicity and ability of stimulating AM to se-crete biomedium bv the three dusts, the effect of flaxwas weakest.