亚硒酸钠对青石棉诱发大鼠间皮瘤的阻断作用与血浆过氧化脂质关系的研究

Relationship between Effect of Sodium Selenite on Blocking Mesothelioma Induced by Crocidolite and Level of Serum Lipid Peroxidation in Rats

本文探讨了亚硒酸钠阻断间皮瘤的作用规律及其与过氧化脂质的关系。实验结果表明：５ｐｐｍ亚硒酸钠溶液不但可阻断间皮瘤的形成，减缓其生长速度，还可对抗青石棉诱发的过氧化反应。这表现在给硒组，在４３０天和５３０天两个时间段，间皮瘤发生率和过氧化脂质量与阳性对照组比显著降低（Ｐ＜０．００５）；间皮瘤首例死亡时间（３４１天）和死亡高峰期（５３０～６３０天）与阳性对照组（２３７天，４３０～５３０天）比后延；给硒组和阳性对照组Ｇ值在不同实验段的变化趋于一致（ｒ＝０．９９９１）。这些结果可为间皮瘤机理的研究和进一步防治提供依据。

This paper reports the relationship time the effect of sodium selenite on blocking mesothelioma induced by crocidolite and the level ofserum lipid peroxidation in rats. The result showedthat sodium selenite solution ( 5ppm ) might not onlyblock and slow dovvn the formation and growth ofmesothelioma but also prevent peroxidation producedbvcrocidolite.The incidence of mesothelioma and the content of LPO in the Se group were lower than thosein the positive control group in different periods(0 430 days and 0 530 days respectively). The survivaltime(341 days)of the first case of mesothelioma andthe death peak period(530 630 days)in the se groupwere longer than those ( 237 days and 430 530 daysrespectively)in the posit ive group.There was a goodcorrelation between the change of G value in the Segroup and tbe change of G value in the positive controlgroup in different experimental periods(r=0. 9991).These results will provide scientific bases for recogniz-ing the mechanism of mesothelioma and for furtheringtke practice in the people exposed to asbestos.