对－取代苯甲酰氨基苯甲酸（甲酯）的合成及其分化诱导HL－60细胞活性试验

Synthesis of p-Substituted Benzoylaminobenzoic Acid (Methyl Esters)and Its Differentiation Induction in Activities of Human Promyelocytic Leukemia Cells HL-60

作者合成了１６个对－苯甲酰氨基苯甲酸（甲酯），并进行了分化诱导人髓系白血病细胞（ＨＬ－６０细胞）的活性试验，其中有４个化合物活性较强，在浓度为１０￣（－６）ｍｏｌ／Ｌ时可使２５％～５０％以上的早幼粒细胞分化为较成熟细胞；有两个化合物在浓度为５×１０￣（－６）ｍｏｌ／Ｌ时可使细胞分化率提高到７０％，但较维Ａ酸分化率（９７％）为低。

Sixteen p-substituted benzoylaminobenoic acids and their metyl esters were synthesized of which nine were not found in literature All of the thpic compounds were evaluated for their differentia-tion indution in activities of human promyelotic