四川地区儿童恶性淋巴瘤──附304例临床病理分析

Malignant Lymphomas in Childhood in Sichuan Province──A Clinicopathological Analysis of 304 Cases

作者回顾性分析四川地区儿童恶性淋巴瘤３０４例，其中何杰金氏病（ＨＤ）１６０例，男女之比为５．７：１，好发年龄５～９岁，好发部位为颈淋巴结，未发生于淋巴结外器官。累及骨髓（１例）占０．６％，混合细胞型（１００例）占６２．５％，预后比非何杰金氏淋巴瘤（ＮＨＬ）好。ＮＨＬ１４４例，男女之比为３．４：１，好发年龄４～１４岁，首发部位以表浅淋巴结为多，淋巴结外器官发生（２ｓ）例）占１６．０％，累及骨髓（１９例）占１３．２％，淋巴母细胞型（６４例）占４４．５％，高度恶性组（１０５例）占７２．９％，滤泡型罕见（１例）占０．７％。作者对我国儿童ＨＤ和ＮＨＬ的特点进行了讨论。

A clinicopathological study of 304 casesof malignant lymphomas(ML)in children in Sichuanprovince is reported.One hundred a nd si xty of themwere Hodgkin’s disease(HD).The ratio betweenmales and females was 5. 7 to 1.The disease was moreprevalent in children aged from 5 to 9. Cervical lymphnodes were more easily involved. Extra-nodal HDwasn’t found in these cases. When subtypes of HDwere concerned 62.5%of cases belonged to mixed-cel-lularity HD. The prognosis of HD was better than thatof non-Hodgkin’s lymphoma(NHL).The remaining144 cases. were NHL. The tatio between males and fe-males was 3. 4 to 1.The disease was more prevalent inchildren aged from 4 to 14. Eighty four percent ofNHL primarily originated from superficial lymph nodesand the other 16.0%of NHL was of extranodal in-volvement. Seventy two point nine percent of cases inthis group was of high grade malignancy. Among themthe lymphoblastic type of NHL occupied 44.5%, Onthe other hand,the follicular type of NHL was rare(0.7%). The specialities of malignant lymphomas inchildhood in China are also discussed in the present re-port.