苯妥英钠和卡马西平对男性癫痫患者性激素影响的对比研究

Effects of Phenytoin and Cabamazepine on Sex Hormones in Male Patients with Epilepsy :A Controlled Study

用放射免疫测定法测定２４例单服苯妥英钠（ＤＰＨ），２１例单服卡马西平（ＣＢＺ）的男性癫痫患者的血清性激素水平，包括总睾酮（ＴＴ）、游离睾酮（ＦＴ）和雌二醇（Ｅ＿２），并与１０例性功能正常男性和２３例未服抗癫痫药的男性患者对比。结果发现ＤＰＨ引起ＴＴ和Ｅ＿２升高，ＣＢＺ则引起下降。说明两种药物对性激素的影响机理不同，因而处理也不尽相同。

We measured the levels of estradiol(E_2),total testosterone(TT)and free testosterone( FT)in 24 male patients with epilepsy receivingphenytoin(DPH),21 male patients with epileps re-ceiving cabamazepine(CBZ),23 male epileptics re-celving no treatment. and in 10 healthy age-matchedmale controls. The FT and TT levels of the DPHgroup were significantly lower and higher than thoseof the normal control group,respectively. The E_2 , FTand TT of the CBZ group were all lower than those ofthe normal controls.The results showed the differ-ence between DPH and CBZ in the mechanism ofaffecting the levels of sex hormones; therefore, thetreatments should not be the same.